N-Deacetylcolchicine (tartrate)

N-Deacetylcolchicine tartrate is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. N-Deacetylcolchicine tartrate is a derivative of Colchicine (HY-16569) . N-Deacetylcolchicine tartrate can activate the GTPase activity of microtubules and can be used for the research of cancer[1][2].

Product Specifications

CAS Number

[49720-72-1]

UNSPSC

12352005

Target

Arf Family GTPase; Drug Derivative; Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

OC([C@H](O)[C@@H](O)C(O)=O)=O.O=C1C=C2[C@@H](N)CCC3=CC(OC)=C(OC)C(OC)=C3C2=CC=C1OC

Molecular Formula

C24H29NO11

Molecular Weight

507.49

References & Citations

[1]Muzaffar, A., et al. Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J. Med. Chem. 33 (2), 567-571 (1990) .|[2]Lin, et al. Effects of inhibitors of tubulin polymerization on GTP hydrolysis. The Journal of Biological Chemisty 256 (17), 9242-9245 (1981) .