Vestipitant (mesylate)

Vestipitant (GW597599) mesylate is a selective, orally active, and blood-brain barrier penetrant NK1 receptor antagonist. Vestipitant mesylate exhibits high affinity for the human NK1 receptor (pKi: 9.65) . Vestipitant mesylate can be used in the research of diseases such as depression, anxiety disorders, and nausea and vomiting[1][2].

Product Specifications

CAS Number

[334476-64-1]

Product Name Alternative

GW597599 (mesylate) ; GW597599B

UNSPSC

12352005

Hazard Statement

H302-H413

Target

Neurokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(N1CCNC[C@@H]1C2=CC=C(F)C=C2C)N([C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)C.CS(=O)(O)=O

Molecular Formula

C24H28F7N3O4S

Molecular Weight

587.55

Precautions

P264-P270-P273-P330-P501

References & Citations

[1]Guercio G, et al. Synthesis of the NK1 receptor antagonist GW597599. Part 1: development of a scalable route to a key chirally pure arylpiperazine. Organic Process Research & Development, 2008, 12 (6) : 1188-1194.|[2]Di Fabio R, et al. Discovery process and pharmacological characterization of 2- (S) - (4-fluoro-2-methylphenyl) piperazine-1-carboxylic acid [1- (R) - (3, 5-bis-trifluoromethylphenyl) ethyl] methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist. Journal of medicinal chemistry, 2009, 52 (10) : 3238-3247.