DMP 904

DMP 904 is a noncompetitive full corticotropin-releasing factor receptor (CRFR) antagonist. DMP 904 can inhibit CRF-stimulated adenylate cyclase activity and ACTH release. DMP 904 exhibits anti-depressant and anti-anxiety activity[1][2].

Product Specifications

CAS Number

202579-74-6

UNSPSC

12352005

Target

Adenylate Cyclase; CRFR

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease

Smiles

CC1=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN2C(NC(CC)CC)=C1

Molecular Formula

C21H28N4O

Molecular Weight

352.47

References & Citations

[1]Li YW, et al. The pharmacology of DMP696 and DMP904, non-peptidergic CRF1 receptor antagonists. CNS Drug Rev. 2005 Spring;11 (1) :21-52.|[2]Nielsen DM, et al. Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice. Eur J Pharmacol. 2004 Sep 19;499 (1-2) :135-46.