Bromotetrandrine
Bromotetrandrine is a potent inhibitor of P-glycoprotein (P-gp) -mediated multidrug resistance (MDR) . Bromotetrandrine shows significant MDR reversal activity in vitro and in vivo, which may be related to the inhibition of P-gp overexpression and the increase in intracellular accumulation of anticancer agents. Bromotetrandrine is a brominated derivative of tetrandrine, which is promising for MDR modulator for tumor assessment[1][2].
Product Specifications
CAS Number
62067-29-2
Product Name Alternative
5-Bromotetrandrine; BrTet; W198
UNSPSC
12352005
Target
Drug Derivative; P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC1=C2C3=C(CCN([C@@]3([H])CC4=CC=C(OC)C(OC5=CC=C(C[C@@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4)C)C(Br)=C1OC
Molecular Formula
C38H41BrN2O6
Molecular Weight
701.65
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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