Bevantolol-d7 (hydrochloride)

Bevantolol-d7 hydrochloride is the deuterium labeled Bevantolol hydrochloride (HY-121186) . Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist[1][2].

Product Specifications

UNSPSC

12352005

Target

Adrenergic Receptor; Calcium Channel; Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Metabolic Disease; Neurological Disease

Smiles

OC(CNCCC1=CC=C(C(OC)=C1)OC)COC2=C([2H])C([2H])=C([2H])C(C([2H])([2H])[2H])=C2[2H].Cl

Molecular Formula

C20H21D7ClNO4

Molecular Weight

388.94

References & Citations

[1]M Takita, et al. Selectivity of Bevantolol Hydrochloride Towards Alpha- And Beta-Adrenoceptor Subtypes in Rat Cerebral Cortex. Jpn J Pharmacol. 1992 Feb;58 (2) :193-6. |[2]Takahiro Horinouchi, et al. Different Changes of Plasma Membrane Beta-Adrenoceptors in Rat Heart After Chronic Administration of Propranolol, Atenolol and Bevantolol. Life Sci. 2007 Jul 12;81 (5) :399-404.