Hexoprenaline (sulfate)

Hexoprenaline sulfate is an orally active and selective β-adrenergic receptor agonist. Hexoprenaline sulfate can dilate the bronchi. Hexoprenaline sulfate can activate adenylate cyclase and increases 14C-Aminopyrine uptake. Hexoprenaline sulfate exhibits anti-infection and anti-inflammmation effect. Hexoprenaline sulfate can increase placental weight and blood flow. Hexoprenaline sulfate can be used for the researches of inflammation, immunology, infection, endocrinology and neurological disease, such as asthma, chronic bronchitis, sepsis and intoxication of organophosphorus compounds[1][2][3][4][5].

Product Specifications

CAS Number

[32266-10-7]

UNSPSC

12352005

Hazard Statement

H331-H412

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Infection; Endocrinology; Inflammation/Immunology; Neurological Disease

Solubility

10 mM in DMSO

Smiles

OC(CNCCCCCCNCC(O)C1=CC=C(C(O)=C1)O)C2=CC=C(C(O)=C2)O.OS(O)(=O)=O

Molecular Formula

C22H34N2O10S

Molecular Weight

518.58

Precautions

P261-P271-P273-P304+P340-P403+P233-P405-P501

References & Citations

[1]Schonell M, et al. Bronchodilator effect of hexoprenaline aerosol in bronchial asthma and chronic bronchitis. Med J Aust. 1977 Dec 17;2 (25) :828-30.|[2]Ruoff HJ, et al. Adrenergic stimulation of isolated rat gastric mucosal cells. Effect on adenylate cyclase and 14C-aminopyrine uptake. Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320 (2) :175-81.|[3]Zabrodskii P F. et al. The Mechanisms of the Cholinergic Anti-Inflammatory Pathway after Acute Intoxication of Organophosphorus Compounds[J]. Biomedical Journal, 2010, 1: 5.|[4]Zabrodskii P F. et al. The influence of various drugs on mortality of mice and the concentration of proinflammatory cytokines in blood at sepsis caused by E. coli[J]. Acta scientific microbiology, 2018, 1: 11-14.|[5]Lipshitz J, et al. Effect of long-term administration of beta 2-sympathomimetic drug in the diet-restricted pregnant rat model. Am J Obstet Gynecol. 1986 Feb;154 (2) :314-7.