GSK172981

GSK172981 is a brain-penetrant tachykinin NK3 receptor antagonist with pKi values of 7.7 and 7.8 for human and native guinea pig NK3 receptors, respectively. GSK172981 can be used for the study of schizophrenia[1].

Product Specifications

CAS Number

[1133705-99-3]

UNSPSC

12352005

Target

Neurokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(N[C@H](C1=CC=CC=C1)C2CC2)C3=C(C(C4=CC=CC(F)=C4)=NC5=CC=CC=C35)N

Molecular Formula

C26H22FN3O

Molecular Weight

411.47

References & Citations

[1]Dawson LA, et al. In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics. Eur J Pharmacol. 2010 Feb 10;627 (1-3) :106-14.