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Fexarene

Fexarene is a potent and selective nonsteroidal Farnesoid X Receptor (FXR) agonist with an EC50 of 36 nM. Fexarene can be used in studies of cholesterol and bile acid metabolism[1].

Product Specifications

CAS Number

[574013-68-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

FXR

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C(/C=C/C1=CC=CC(N(CC2=CC=C(C=C2)/C=C/C3=CC=CC=C3)C(C4CCCCC4)=O)=C1)OC

Molecular Formula

C32H33NO3

Molecular Weight

479.61

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Nicolaou KC, et al. Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org Biomol Chem. 2003 Mar 21;1 (6) :908-20.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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