AMG8163
AMG8163 is an orally active antagonist for TRPV1. AMG8163 inhibits Capsaicin -induced flinch in rats models, and exhibits anti-hyperalgesia effects in multiple pain models[1].
Product Specifications
CAS Number
659731-59-6
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(NC1=CC(C(F)(F)F)=CC=C1C2=NC=NC(OC3=C4N=C(SC4=CC=C3)NC(C)=O)=C2)OC(C)(C)C
Molecular Formula
C25H22F3N5O4S
Molecular Weight
545.53
References & Citations
[1]Gavva NR, et al., Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther. 2007 Oct;323 (1) :128-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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