AMG8163

AMG8163 is an orally active antagonist for TRPV1. AMG8163 inhibits Capsaicin (HY-10448) -induced flinch in rats models, and exhibits anti-hyperalgesia effects in multiple pain models[1].

Product Specifications

CAS Number

[659731-59-6]

UNSPSC

12352005

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(NC1=CC(C(F)(F)F)=CC=C1C2=NC=NC(OC3=C4N=C(SC4=CC=C3)NC(C)=O)=C2)OC(C)(C)C

Molecular Formula

C25H22F3N5O4S

Molecular Weight

545.53

References & Citations

[1]Gavva NR, et al., Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther. 2007 Oct;323 (1) :128-37.