PF-514273
PF-514273 is an orally active, selective antagonist for cannabinoid-1 receptor (CB1) with IC50 of 1 nM. PF-514273 reduces the food uptake in mice, and can be used for obesity research[1].
Product Specifications
CAS Number
851728-60-4
UNSPSC
12352005
Target
Cannabinoid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Smiles
O=C1N(CC(F)(F)C)CCOC2=C(C3=CC=C(Cl)C=C3)N(C4=CC=CC=C4Cl)N=C12
Molecular Formula
C21H17Cl2F2N3O2
Molecular Weight
452.28
References & Citations
[1]Dow RL, et al., Discovery of 2- (2-chlorophenyl) -3- (4-chlorophenyl) -7- (2,2-difluoropropyl) -6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8 (5H) -one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. J Med Chem. 2009 May 14;52 (9) :2652-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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