PF-514273

PF-514273 is an orally active, selective antagonist for cannabinoid-1 receptor (CB1) with IC50 of 1 nM. PF-514273 reduces the food uptake in mice, and can be used for obesity research[1].

Product Specifications

CAS Number

[851728-60-4]

UNSPSC

12352005

Target

Cannabinoid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Metabolic Disease

Smiles

O=C1N(CC(F)(F)C)CCOC2=C(C3=CC=C(Cl)C=C3)N(C4=CC=CC=C4Cl)N=C12

Molecular Formula

C21H17Cl2F2N3O2

Molecular Weight

452.28

References & Citations

[1]Dow RL, et al., Discovery of 2- (2-chlorophenyl) -3- (4-chlorophenyl) -7- (2,2-difluoropropyl) -6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8 (5H) -one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. J Med Chem. 2009 May 14;52 (9) :2652-5.