BS148
BS148 is a selective sigma-2 receptor (S2R) agonist with a Ki 20 nM. BS148 shows >80-fold selective for S2R than S1R. BS148 activates the endoplasmic reticulum stress response through the upregulation of protein kinase R-like ER kinase (PERK), activating transcription factor 4 (ATF4) genes, and C/EBP homologous protein (CHOP) . BS148 induces apoptosis in melanoma cell. BS148 downregulates genes related to the cholesterol pathway and activates the MAPK signaling pathway. BS148 can be used for the study of melanoma[1][2].
Product Specifications
CAS Number
2162116-09-6
UNSPSC
12352005
Target
Apoptosis; p38 MAPK; Sigma Receptor
Related Pathways
Apoptosis; MAPK/ERK Pathway; Neuronal Signaling
Field of Research
Cancer
Smiles
N1(CC2SC3(CCCCC3)SC2)CCC(CC4=CC=CC=C4)CC1
Molecular Formula
C21H31NS2
Molecular Weight
361.61
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor; Sigma 2 Receptor
Frequently Asked Questions
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