BS148

BS148 is a selective sigma-2 receptor (S2R) agonist with a Ki 20 nM. BS148 shows >80-fold selective for S2R than S1R. BS148 activates the endoplasmic reticulum stress response through the upregulation of protein kinase R-like ER kinase (PERK), activating transcription factor 4 (ATF4) genes, and C/EBP homologous protein (CHOP) . BS148 induces apoptosis in melanoma cell. BS148 downregulates genes related to the cholesterol pathway and activates the MAPK signaling pathway. BS148 can be used for the study of melanoma[1][2].

Product Specifications

CAS Number

[2162116-09-6]

UNSPSC

12352005

Target

Apoptosis; p38 MAPK; Sigma Receptor

Related Pathways

Apoptosis; MAPK/ERK Pathway; Neuronal Signaling

Field of Research

Cancer

Smiles

N1(CC2SC3(CCCCC3)SC2)CCC(CC4=CC=CC=C4)CC1

Molecular Formula

C21H31NS2

Molecular Weight

361.61

References & Citations

[1]Claudia Sorbi, et al. BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting. Int J Mol Sci. 2023 Jun 2;24 (11) :9684.|[2]Franchini S, et al. Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma. ChemMedChem. 2017 Nov 22;12 (22) :1893-1905.