CCT077791
CCT077791 is a PCAF (IC50: 7.3 μM (FlashPlate) ; 2.2 μM (Filter assay) ) and p300 histone acetyltransferase inhibitor. CCT077791 reduces total acetylation of histones H3 and H4, levels of specific acetylated lysine marks, and acetylation of α-tubulin. CCT077791 can be used in the research of colorectal cancer[1].
Product Specifications
CAS Number
748777-47-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Histone Acetyltransferase; Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics
Field of Research
Cancer
Smiles
O=C1C=C(SN1C2=CC=C([N+]([O-])=O)C=C2)Cl
Molecular Formula
C9H5ClN2O3S
Molecular Weight
256.67
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Stimson L, et al. Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity. Mol Cancer Ther. 2005 Oct;4 (10) :1521-32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300; GCN5/PCAF
Frequently Asked Questions
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