N-Arachidonoyl-L-serine

N-Arachidonoyl-L-serine (ARA-S) is an endocannabinoid. N-Arachidonoyl-L-serine induces phosphorylation of Akt and MAPK in endothelial cells. N-Arachidonoyl-L-serine also induces endothelium-dependent vasodilation in isolated rat mesenteric and abdominal aortas. N-Arachidonoyl-L-serine exhibits neuroprotective effects after traumatic brain injury by reducing apoptosis. N-Arachidonoyl-L-serine promotes the opening of KV7.1/KCNE1 channels in mammalian cells and shortens the action potential duration in cardiomyocytes. N-Arachidonoyl-L-serine may be used in research on cardiovascular and cerebrovascular diseases and neurological disorders[1][2][3].

Product Specifications

CAS Number

[187224-29-9]

Product Name Alternative

ARA-S

UNSPSC

12352211

Hazard Statement

H225-H350

Target

Akt; Apoptosis; p38 MAPK; Potassium Channel

Related Pathways

Apoptosis; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR

Field of Research

Neurological Disease; Cardiovascular Disease

Smiles

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N[C@H](C(O)=O)CO)=O

Molecular Formula

C23H37NO4

Molecular Weight

391.54

Precautions

P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P405-P501

References & Citations

[1]Cohen-Yeshurun A, et al. N-arachidonoyl-L-serine is neuroprotective after traumatic brain injury by reducing apoptosis. J Cereb Blood Flow Metab. 2011 Aug;31 (8) :1768-77.|[2]Milman G, et al. N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties. Proc Natl Acad Sci U S A. 2006 Feb 14;103 (7) :2428-33. |[3]Hiniesto-Iñigo I, et al. Rescue of loss-of-function long QT syndrome-associated mutations in KV7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S) . Br J Pharmacol. 2025 Jul;182 (13) :2861-2877.