(R) -MMP408

(R) -MMP408 is an isomer of MMP408 (HY-12093) . MMP408 is a potent and selective MMP-12 inhibitor that is derived from a potent matrix metalloprotease-2 and -13 inhibitor via lead optimization. MMP408 can block rhMMP-12-induced lung inflammation in vivo. MMP408 can be studied in research on COPD[1].

Product Specifications

CAS Number

[1258003-93-8]

UNSPSC

12352005

Target

MMP

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)[C@H](C(O)=O)NS(=O)(C1=CC=C2C(OC3=CC=C(NC(OC)=O)C=C23)=C1)=O

Molecular Formula

C19H20N2O7S

Molecular Weight

420.44

References & Citations

[1]Li, W., et al., A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD) : discovery of (S) -2- (8- (methoxycarbonylamino) dibenzo[b, d]furan-3-sulfonamido) -3-methylbutanoic acid (MMP408) . Journal of medicinal chemistry, 52 (7), 1799–1802.