JYL-273 analog-1

JYL-273 analog-1 (Compound 28, Example 45) is a potent transient receptor potential ion channel (TRP channel) (TRPV1) agonist (Ki = 10.8 nM) . JYL-273 analog-1 has analgesic activity (PBQ-induced writhing test: ED50 = 1.0 mg/kg) . JYL-273 analog-1 can be used for analgesia studies[1][2].

Product Specifications

CAS Number

[289902-71-2]

UNSPSC

12352005

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CC(C)(C)C(OCC(CNC(NCC1=CC=C(O)C(OC)=C1)=S)CC2=CC=C(C(C)(C)C)C=C2)=O

Molecular Formula

C28H40N2O4S

Molecular Weight

500.69

References & Citations

[1]Jeewoo Lee, et al. Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof. WO2000050387. 2001-08-22. |[2]Lee J, et al. N- (3-Acyloxy-2-benzylpropyl) -N'- (4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics. Bioorg Med Chem. 2001 Jan;9 (1) :19-32.