JYL-273 analog-1
JYL-273 analog-1 (Compound 28, Example 45) is a potent transient receptor potential ion channel (TRP channel) (TRPV1) agonist (Ki = 10.8 nM) . JYL-273 analog-1 has analgesic activity (PBQ-induced writhing test: ED50 = 1.0 mg/kg) . JYL-273 analog-1 can be used for analgesia studies[1][2].
Product Specifications
CAS Number
289902-71-2
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC(C)(C)C(OCC(CNC(NCC1=CC=C(O)C(OC)=C1)=S)CC2=CC=C(C(C)(C)C)C=C2)=O
Molecular Formula
C28H40N2O4S
Molecular Weight
500.69
References & Citations
[1]Jeewoo Lee, et al. Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof. WO2000050387. 2001-08-22. |[2]Lee J, et al. N- (3-Acyloxy-2-benzylpropyl) -N'- (4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics. Bioorg Med Chem. 2001 Jan;9 (1) :19-32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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