GUT-70
GUT-70, a tricyclic coumarin, is a Hsp90 inhibitor. GUT-70 activates the caspase 2, 3, 8 and 9, and induces the apoptosis in leukemic cells. GUT-70 inhibits HIV-1 replication in chronically infected cells via suppression of the NF-κB pathway. GUT-70 can be used for the study of leukemic, mantle cell lymphoma (MCL) and HIV-1 infection[1][2][3].
Product Specifications
CAS Number
161633-75-6
UNSPSC
12352005
Target
Apoptosis; Caspase; HIV; HSP; NF-κB
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Infection
Smiles
O=C1C=C(CCC)C2=C3C(C=CC(C)(C)O3)=C(OC)C(C(/C(C)=C/C)=O)=C2O1
Molecular Formula
C23H26O5
Molecular Weight
382.45
References & Citations
[1]Kimura S, et al. Inhibition of leukemic cell growth by a novel anti-cancer drug (GUT-70) from calophyllum brasiliense that acts by induction of apoptosis. Int J Cancer. 2005 Jan 1;113 (1) :158-65.|[2]Jin L, et al. Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma. Br J Cancer. 2011 Jan 4;104 (1) :91-100. |[3]Matsuda K, et al. Inhibition of HIV-1 entry by the tricyclic coumarin GUT-70 through the modification of membrane fluidity. Biochem Biophys Res Commun. 2015 Feb 13;457 (3) :288-94.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 2; Caspase 3; Caspase 8; Caspase 9; HIV-1; HSP90; NF-κB
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