BRD1172

BRD1172 (ML320) is a selectivity GSK3β inhibitor with an IC50 of 24 nM for GSK3β over CDK5. BRD1172 significantly inhibits GSK3β-mediated Tau phosphorylation in SH-SY5Y cells, and relieves negative regulation by GSK3β on β-catenin degradation and TCF/LEF promoter activities. BRD1172 can be used for Alzheimer’s disease, cardiac hypertrophy and cancers research[1].

Product Specifications

CAS Number

[1597438-86-2]

Product Name Alternative

ML320

UNSPSC

12352005

Target

GSK-3; β-catenin

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Smiles

FC(F)(C1=C2[C@H](C3=C(C=CC=C3)OC)C4=C(CC(C)(CC4=O)C)NC2=NN1)F

Molecular Formula

C20H20F3N3O2

Molecular Weight

391.39

References & Citations

[1]An WF, et al. Discovery of Potent and Highly Selective Inhibitors of GSK3b. 2012 Apr 16 [updated 2014 May 13]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD) : National Center for Biotechnology Information (US) ; 2010–.