LY2109761 (Standard)
LY2109761 (Standard) is the analytical standard of LY2109761. This product is intended for research and analytical applications. LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with Kis of 38 nM and 300 nM, respectively.
Product Specifications
CAS Number
700874-71-1
UNSPSC
12352100
Target
Autophagy; Reference Standards; TGF-β Receptor
Related Pathways
Autophagy; Others; TGF-beta/Smad
Field of Research
Cancer
Smiles
N12N=C(C(C3=C4C=CC(OCCN5CCOCC5)=CC4=NC=C3)=C1CCC2)C6=NC=CC=C6
Molecular Formula
C26H27N5O2
Molecular Weight
441.52
References & Citations
[1]Melisi D, et al. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther, 2008, 7 (4), 829-840.|[2]Fransvea E, et al. Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology, 2008, 47 (5), 1557-1566.|[3]Zhang M, et al. Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. Cancer Res, 2011, 71 (23), 7155-7167.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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