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LDN-193189 (dihydrochloride) (Standard)

LDN-193189 (dihydrochloride) (Standard) is the analytical standard of LDN-193189 (dihydrochloride) . This product is intended for research and analytical applications. LDN-193189 (dihydrochloride) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva[1][2][3].

Product Specifications

CAS Number

1435934-00-1

UNSPSC

12352100

Target

Organoid; Reference Standards; TGF-β Receptor

Related Pathways

Others; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer

Smiles

C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16.Cl.Cl

Molecular Formula

C25H24Cl2N6

Molecular Weight

479.40

References & Citations

[1]Yu PB, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med, 2008, 14 (12), 1363-1369.|[2]Daniel Horbelt, et al. Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation. J Biol Chem. 2015 Feb 6;290 (6) :3390-404.|[3]Julien Vollaire, et al. The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice. Front Pharmacol. 2019 Jun 19;10:667.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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