LDN193189 (Tetrahydrochloride) (Standard)
LDN193189 (Tetrahydrochloride) (Standard) is the analytical standard of LDN193189 (Tetrahydrochloride) . This product is intended for research and analytical applications. LDN193189 Tetrahydrochloride is a selective BMP type I receptor inhibitor, which efficiently inhibits ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on ALK4, ALK5 and ALK7 (IC50≥500 nM) [1].
Product Specifications
CAS Number
2310134-98-4
UNSPSC
12352100
Target
Organoid; Reference Standards; TGF-β Receptor
Related Pathways
Others; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Smiles
C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16.Cl.Cl.Cl.Cl
Molecular Formula
C25H26Cl4N6
Molecular Weight
552.33
References & Citations
[1]Yu PB, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med, 2008, 14 (12), 1363-1369.|[2]Lee YC, et al. BMP4 promotes prostate tumor growth in bone through osteogenesis. Cancer Res, 2011, 71 (15), 5194-5203.|[3]Yang L, et al. UK-92480 increases connexin 40 in smooth muscle cells through activation of BMP pathways in pulmonary arterial hypertension. Int J Clin Exp Pathol. 2014 Jul 15;7 (8) :4674-84.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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