LDN193189 (Tetrahydrochloride) (Standard)

LDN193189 (Tetrahydrochloride) (Standard) is the analytical standard of LDN193189 (Tetrahydrochloride) . This product is intended for research and analytical applications. LDN193189 Tetrahydrochloride is a selective BMP type I receptor inhibitor, which efficiently inhibits ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on ALK4, ALK5 and ALK7 (IC50≥500 nM) [1].

Product Specifications

CAS Number

[2310134-98-4]

UNSPSC

12352100

Target

Organoid; Reference Standards; TGF-β Receptor

Related Pathways

Others; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer

Smiles

C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16.Cl.Cl.Cl.Cl

Molecular Formula

C25H26Cl4N6

Molecular Weight

552.33

References & Citations

[1]Yu PB, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med, 2008, 14 (12), 1363-1369.|[2]Lee YC, et al. BMP4 promotes prostate tumor growth in bone through osteogenesis. Cancer Res, 2011, 71 (15), 5194-5203.|[3]Yang L, et al. UK-92480 increases connexin 40 in smooth muscle cells through activation of BMP pathways in pulmonary arterial hypertension. Int J Clin Exp Pathol. 2014 Jul 15;7 (8) :4674-84.