4-Epianhydrochlortetracycline (hydrochloride)
4-Epianhydrochlortetracycline hydrochloride is an inhibitor of matrix metalloproteinases (MMPs), particularly gelatinase B (Gelatinase B, EC 3.4.24.35), with inhibition rates of 100% at 500 μg/mL, 70% at 125 μg/mL, and 40% at 31 μg/mL. 4-Epianhydrochlortetracycline hydrochloride is promising for research in chronic inflammatory diseases[1].
Product Specifications
CAS Number
158018-53-2
UNSPSC
12352005
Hazard Statement
H302-H319-H361
Target
MMP
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O[C@]12[C@](CC(C(C2=O)=C(C3=C(O)C=C4)O)=C(C)C3=C4Cl)([H])[C@H](C(O)=C(C1=O)C(N)=O)N(C)C.Cl
Molecular Formula
C22H22Cl2N2O7
Molecular Weight
497.33
Precautions
P264-P270-P280-P305+P351+P338-P330-P405-P501
References & Citations
[1]Paemen L, et al. The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors. Biochem Pharmacol. 1996 Jul 12;52 (1) :105-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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