4-Epianhydrochlortetracycline (hydrochloride)

4-Epianhydrochlortetracycline hydrochloride is an inhibitor of matrix metalloproteinases (MMPs), particularly gelatinase B (Gelatinase B, EC 3.4.24.35), with inhibition rates of 100% at 500 μg/mL, 70% at 125 μg/mL, and 40% at 31 μg/mL. 4-Epianhydrochlortetracycline hydrochloride is promising for research in chronic inflammatory diseases[1].

Product Specifications

CAS Number

[158018-53-2]

UNSPSC

12352005

Hazard Statement

H302-H319-H361

Target

MMP

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

O[C@]12[C@](CC(C(C2=O)=C(C3=C(O)C=C4)O)=C(C)C3=C4Cl)([H])[C@H](C(O)=C(C1=O)C(N)=O)N(C)C.Cl

Molecular Formula

C22H22Cl2N2O7

Molecular Weight

497.33

Precautions

P264-P270-P280-P305+P351+P338-P330-P405-P501

References & Citations

[1]Paemen L, et al. The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors. Biochem Pharmacol. 1996 Jul 12;52 (1) :105-11.