BMS-955829
BMS-955829 is an orally active and selective mGluR5 positive allosteric modulator with an EC50 of 2.6 nM. BMS-955829 has no intrinsic agonist activity and a low glutamate fold shift (2.4) . BMS-955829 can effectively improve cognitive and executive function deficits in rodents. BMS-955829 can be used in the research of cognitive impairment diseases such as schizophrenia[1].
Product Specifications
CAS Number
1375751-08-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MGluR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C1O[C@H](C2=CC(F)=CC=C2F)[C@@H](C3=CC(C#CC4=CC=CC=C4)=CN=C3)N1
Molecular Formula
C22H14F2N2O2
Molecular Weight
376.36
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Yang F, et al. Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5. ACS Med Chem Lett. 2016 Jan 4;7 (3) :289-93.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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