BMS-229724
BMS-229724 is an orally active and tight-binding cytosolic phospholipase A2 (cPLA2) inhibitor with an IC50 of 2.8 μM. BMS-229724 can inhibit the production of arachidonic acid and eicosanoids in U937 cells, neutrophils, platelets, and other cells. BMS-229724 has anti-inflammatory activity and can be used in the research of diseases such as skin inflammation[1][2].
Product Specifications
CAS Number
221914-85-8
UNSPSC
12352005
Target
Phospholipase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(CCC1=CC=C(OCCS(=O)(CCOC(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)=O)C=C1)C(F)(F)F
Molecular Formula
C27H25Cl2F3O5S
Molecular Weight
589.45
References & Citations
[1]Magrioti V, et al. Synthetic inhibitors of group IVA and group VIA phospholipase A2[J]. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistryrrent Medicinal Chemistry-Anti-Inflammatory and Anti-Allergy Agents), 2006, 5 (2) : 189-203.|[2]Burke JR, et al. BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. J Pharmacol Exp Ther. 2001 Jul;298 (1) :376-85.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Phospholipase A
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