BMS-520

BMS-520 is a potent, orally active and selective sphingosine-1-phosphate 1 (S1P1) agonist with an EC50 of 0.47nM. BMS-520 shows ~3400-fold selectivity over S1P3. BMS-520 demonstrates impressive efficacy in a rat model of arthritis and in a mouse experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. BMS-520 can be used for arthritis and EAE research[1].

Product Specifications

CAS Number

[1236188-38-7]

UNSPSC

12352005

Target

LPL Receptor

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease; Inflammation/Immunology

Smiles

O=C(O)C1CN(C1)CC2=CC=C(C=C2)C3=NOC(C4=C(C(C5=CC=CC=C5)=NO4)C(F)(F)F)=N3

Molecular Formula

C23H17F3N4O4

Molecular Weight

470.40

References & Citations

[1]Watterson SH, et al. Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1) : Discovery and SAR of a Novel Isoxazole Based Series. J Med Chem. 2016 Mar 24;59 (6) :2820-40.