BMS-520
BMS-520 is a potent, orally active and selective sphingosine-1-phosphate 1 (S1P1) agonist with an EC50 of 0.47nM. BMS-520 shows ~3400-fold selectivity over S1P3. BMS-520 demonstrates impressive efficacy in a rat model of arthritis and in a mouse experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. BMS-520 can be used for arthritis and EAE research[1].
Product Specifications
CAS Number
[1236188-38-7]
UNSPSC
12352005
Target
LPL Receptor
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease; Inflammation/Immunology
Smiles
O=C(O)C1CN(C1)CC2=CC=C(C=C2)C3=NOC(C4=C(C(C5=CC=CC=C5)=NO4)C(F)(F)F)=N3
Molecular Formula
C23H17F3N4O4
Molecular Weight
470.40
References & Citations
[1]Watterson SH, et al. Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1) : Discovery and SAR of a Novel Isoxazole Based Series. J Med Chem. 2016 Mar 24;59 (6) :2820-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
S1PR1
Curated Selection
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