BMS-884775

BMS-884775 is a selective and orally active P2Y1 antagonist with an IC50 of 0.1 nM for the human P2Y1 receptor. BMS-884775 has a similar efficacy in preventing arterial thrombosis to Clopidogrel (HY-15283) and Prasugrel (HY-15284), but treatment with BMS-884775 results in shorter bleeding time and lower bleeding risk. BMS-884775 can be used in research related to antiplatelet and arterial thrombosis-associated diseases[1][2].

Product Specifications

CAS Number

[1557206-59-3]

UNSPSC

12352005

Target

P2Y Receptor

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Smiles

O=C(NC1=NC2=CC=C(Cl)N=C2S1)NC3=CC=CC=C3N4CC5(CCN(CC(C)(C)C)CC5)C6=C4C(O)=CC(F)=C6C7=CC=C(F)C=C7

Molecular Formula

C36H35ClF2N6O2S

Molecular Weight

689.22

References & Citations

[1]Wong P, et al. Differential effects of P2Y1 versus P2Y12 receptor antagonism on thrombosis and bleeding in rabbits. European Heart Journal, 2013, 34 (suppl_1) : P1431.|[2]Tscharre M, et al. Novel Antiplatelet Agents in Cardiovascular Disease. J Cardiovasc Pharmacol Ther. 2020 May;25 (3) :191-200.