ITZ-1
ITZ-1 is an orally active and selective extracellular signal-regulated kinase (ERK) -mitogen-activated protein kinase (MAPK) pathway inhibitor with an IC50 of 0.51 μM for inhibiting interleukin-1β (IL-1β) -induced matrix metalloproteinase-13 (MMP-13) production. ITZ-1 reduces MMP-13 expression and suppresses nitric oxide (NO) -induced chondrocyte apoptosi. ITZ-1 is promising for research of osteoarticular diseases[1].
Product Specifications
CAS Number
1180532-17-5
UNSPSC
12352005
Target
ERK; p38 MAPK
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
O=S(C1=CC=C(C)C=C1)(/N=C(C2=C(SCCCC(F)(F)C(F)(F)F)SC(C)=C(C)N23)\NC3=O)=O
Molecular Formula
C20H20F5N3O3S3
Molecular Weight
541.58
References & Citations
[1]Kimura H, et al. The chondroprotective agent ITZ-1 inhibits interleukin-1beta-induced matrix metalloproteinase-13 production and suppresses nitric oxide-induced chondrocyte death. J Pharmacol Sci. 2009 Jun;110 (2) :201-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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