AM-6226

AM-6226 is a potent and orally active G protein coupled receptor 40 (GPR40) full agonist with an EC50 of 0.12 μM. AM-6226 can activate the GPR40 receptors on pancreatic β cells and enteroendocrine L cells, promote insulin secretion in a glucose-dependent manner and also increase the release of incretin hormones (GLP-1, GIP), thereby avoiding the risk of hypoglycemia. AM-6226 can be used for the research of metabolic disease, such as diabetes[1].

Product Specifications

CAS Number

[1449742-87-3]

UNSPSC

12352005

Target

Free Fatty Acid Receptor

Related Pathways

GPCR/G Protein

Field of Research

Metabolic Disease

Smiles

CC1([C@@H](CCC1)C2=C(C3=CC(OC)=CC=C3F)C=CC(COC4=C(C([C@H](CC)CC(O)=O)=CC=C4)F)=C2)C

Molecular Formula

C32H36F2O4

Molecular Weight

522.62

References & Citations

[1]Brown SP, et al. Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. ACS Med Chem Lett. 2018 Jun 6;9 (7) :757-760.