PBT434 (free base)

PBT434 (ATH434) free base is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 free base can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 free base inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 free base prevents the loss of substantia nigra pars compacta neurons (SNpc) . PBT434 free base has the potential for the research of Parkinson’s disease (PD) [1][2].

Product Specifications

CAS Number

[1232840-87-7]

Product Name Alternative

ATH434 (free base)

UNSPSC

12352005

Target

α-synuclein

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C1N(C)C(CNCC)=NC2=C1C(Cl)=CC(Cl)=C2O

Molecular Formula

C12H13Cl2N3O2

Molecular Weight

302.16

References & Citations

[1]Bailey DK, et al. The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells. PLoS One. 2021 Jul 26;16 (7) :e0254794.|[2]Finkelstein DI, et al. The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease. Acta Neuropathol Commun. 2017 Jun 28;5 (1) :53.