WYE-151650

WYE-151650 is a selective JAK-3 inhibitor. WYE-151650 suppresses IL-2-induced STAT-5 phosphorylation and cell proliferation mediated by JAK-3. WYE-151650 is promising for research of autoimmune diseases[1].

Product Specifications

CAS Number

[1141855-86-8]

UNSPSC

12352005

Target

JAK; STAT

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Inflammation/Immunology

Smiles

N#CC1=CC=C2N=CN(C3=NC=C4N(C)C(N([C@@H]5CC[C@@H](O)C6=C5C=CC=C6)C4=N3)=O)C2=C1

Molecular Formula

C24H19N7O2

Molecular Weight

437.45

References & Citations

[1]Lin TH, et al. Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice. Arthritis Rheum. 2010 Aug;62 (8) :2283-93.