WYE-151650
WYE-151650 is a selective JAK-3 inhibitor. WYE-151650 suppresses IL-2-induced STAT-5 phosphorylation and cell proliferation mediated by JAK-3. WYE-151650 is promising for research of autoimmune diseases[1].
Product Specifications
CAS Number
1141855-86-8
UNSPSC
12352005
Target
JAK; STAT
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Smiles
N#CC1=CC=C2N=CN(C3=NC=C4N(C)C(N([C@@H]5CC[C@@H](O)C6=C5C=CC=C6)C4=N3)=O)C2=C1
Molecular Formula
C24H19N7O2
Molecular Weight
437.45
References & Citations
[1]Lin TH, et al. Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice. Arthritis Rheum. 2010 Aug;62 (8) :2283-93.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3; STAT5
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