AEG40826
AEG40826 (HGS1029), a second mitochondria-derived activator of caspases (SMAC) mimetic, is an inhibitor of apoptosis (IAP) inhibitor. AEG40826 degrades cellular IAP1 (cIAP1) and blocks TNF-α pro-survival signaling. AEG40826 can be used for cancer research[1].
Product Specifications
CAS Number
949963-04-6
Product Name Alternative
HGS1029
UNSPSC
12352100
Target
IAP
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
CN[C@@H](C)C(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@@H](C1)NC(C2=CC=C(C=C2)C(N[C@@H]3CN([C@@H](C3)C(N[C@H]4C5=CC=CC=C5CCC4)=O)C([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)=O)=O)C(N[C@H]6C7=CC=CC=C7CCC6)=O)=O)=O
Molecular Formula
C58H80N10O8
Molecular Weight
1045.32
References & Citations
[1]Infante JR, et al. Phase I dose-escalation study of LCL161, an oral inhibitor of apoptosis proteins inhibitor, in patients with advanced solid tumors. J Clin Oncol. 2014 Oct 1;32 (28) :3103-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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