JP-153
JP-153 is the Src-FAK-Paxillin signaling inhibitor. JP-153 inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) . JP-153 reduces VEGF-induced migration and proliferation in retinal endothelial cells. JP-153 can be uesd for the study of neovascular eye disease[1].
Product Specifications
CAS Number
1802937-26-3
UNSPSC
12352005
Target
FAK; Src
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.45
Solubility
DMSO : 200 mg/mL
Smiles
O=C1OC(C2=CC(OC)=C(OC)C(OC)=C2)C3=CC=C4C=CC=CC4=C3N1
Molecular Formula
C21H19NO5
Molecular Weight
365.38
References & Citations
[1]Toutounchian JJ, et al. Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis. Mol Pharmacol. 2017 Jan;91 (1) :1-13. doi: 10.1124/mol.116.105031. Epub 2016 Nov 9. Erratum in: Mol Pharmacol. 2017 Dec;92 (6) :627.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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