SKLB188
SKLB188 is an orally active and potent epidermal growth factor receptor (EGFR) inhibitor (IC50=5 nM) . SKLB188 suppresses MEK/Erk and Akt/mTOR signaling pathways to inhibit head and neck squamous cell carcinoma (HNSCC) proliferation and induce caspase-dependent apoptosis. SKLB188 is promising for research of EGFR-overexpressing solid tumors[1].
Product Specifications
CAS Number
1350545-09-3
UNSPSC
12352005
Target
Apoptosis; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=[N+](C1=CC(NC2=NC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C3N2C6CCCC6)=CC=C1)[O-]
Molecular Formula
C27H31N9O2
Molecular Weight
513.59
References & Citations
[1]Barzegar M, et al. SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling. Br J Cancer. 2017 Oct 10;117 (8) :1154-1163.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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