Elesclomol-d2

Elesclomol-d2 (STA-4783-d2) is a deuterium labeled Elesclomol (HY-12040) . Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis) . Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research[1][2][3][4].

Product Specifications

Product Name Alternative

STA-4783-d2

UNSPSC

12352005

Target

Apoptosis; Cuproptosis; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer

Smiles

S=C(C1=CC=CC=C1)N(NC(C([2H])([2H])C(NN(C(C2=CC=CC=C2)=S)C)=O)=O)C

Molecular Formula

C19H18D2N4O2S2

Molecular Weight

402.53

References & Citations

[1]Peter Tsvetkov, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 Mar 18;375 (6586) :1254-1261.|[2]Peter Tsvetkov, et al. Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 Jul;15 (7) :681-689. |[3]Kirshner JR, et al. Elesclomol induces cancer cell apoptosis through oxidative stress. Mol Cancer Ther. 2008 Aug;7 (8) :2319-27. |[4]Liam M Guthrie, et al. Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice. Science. 2020 May 8;368 (6491) :620-625.