AB1
AB1 is a highly selective S1P2 receptor antagonist (IC50=3.5 nM) . AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors[1].
Product Specifications
CAS Number
[1463912-49-3]
UNSPSC
12352005
Target
Apoptosis; LPL Receptor
Related Pathways
Apoptosis; GPCR/G Protein
Field of Research
Cancer
Smiles
C=CCN1N=C(C)C2=C(C(C)C)C=C(NNC(NC3=CC(Cl)=NC(Cl)=C3)=O)N=C21
Molecular Formula
C19H21Cl2N7O
Molecular Weight
434.32
References & Citations
[1]Li MH, et al. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. 2015 Sep;354 (3) :261-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
S1PR2
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
