GZ-389988
GZ-389988 is a potent pan-TRK inhibitor with IC50 values of 0.3, 0.1, and 0.5 nM for TRKA, TRKB, and TRKC, respectively. GZ-389988 can be used to study NTRK fusion-positive tumors[1].
Product Specifications
CAS Number
[1788906-96-6]
UNSPSC
12352005
Target
Trk Receptor
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
NC1=NC2=CC(C3=CN(C)N=C3)=CN=C2N1CC4=CC=C(OCC5=CC=C(OC)C=C5)C(OC)=C4
Molecular Formula
C26H26N6O3
Molecular Weight
470.52
References & Citations
[1]Liu J, et al. Research Progress on Small Molecules Inhibitors Targeting TRK Kinases. Curr Med Chem. 2023;30 (10) :1175-1192.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkB; TrkC
Curated Selection
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