BMS-871
BMS-871 is an orally active pan-Notch inhibitor with IC50 values of 4/1/4/3 nM for Notch1/2/3/4, respectively. BMS-871 significantly inhibited the proliferation of TALL-1 and MDA-MB-157 cells and demonstrated significant antitumor activity in T-acute lymphoblastic leukemia and triple-negative breast cancer xenograft models. BMS-871 can be used to study leukemia and breast cancer[1].
Product Specifications
CAS Number
[1584631-89-9]
UNSPSC
12352005
Target
Notch
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(N[C@@H]1C(N(C)C2=CC=CC=C2C(C3=CC=CC=C3)=N1)=O)[C@H](CCC(F)(F)F)[C@H](C4=CC=CC=C4)C(N)=O
Molecular Formula
C29H27F3N4O3
Molecular Weight
536.54
References & Citations
[1]Shan W, et al. BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent. Bioorg Med Chem Lett. 2015 May 1;25 (9) :1905-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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