STK899704
STK899704 is a tubulin polymerization inhibitor. STK899704 exhibits broad-spectrum inhibitory activity against various cancer cell lines with IC50 values ranging from 0.2 to 1.0 μM. STK899704 disrupts the mitotic spindle structure, inducing G2/M phase cell cycle arrest. STK899704 inhibits the migration ability of HT29 cells by downregulating the FAK-MEK-ERK signaling pathway, thereby suppressing the expression and activity of MMP-2 and MMP-9. STK899704 activates caspase-3/7/8/9, leading to PARP cleavage and inducing apoptosis. STK899704 induces cellular senescence through the p53 pathway. STK899704 can be used in research on skin cancer, lung cancer, colon cancer, and other cancers[1][2][3].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Caspase; ERK; FAK; MDM-2/p53; MEK; Microtubule/Tubulin; MMP; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(OCC)CN1C(C)=C(/C=N/NC(C2=CC3=C4C=CC=CC4=CC=C3O2)=O)C5=C1C=CC=C5
Molecular Formula
C27H23N3O4
Molecular Weight
453.49
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120339/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7; Caspase 8; Caspase 9; ERK; MEK; MMP-2; MMP-9
CAS Number
[1578247-29-6]
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