Cis-V-11-0711
Cis-V-11-0711 is the cis form of V-11-0711 (HY-120337) . V-11-0711 is a potent and selective Chk-α (IC50 = 20 nM) inhibitor. V-11-0711 can significantly reduce PCho levels. V-11-0711 causes a reversible growth arrest. V-11-0711 induces apoptosis at high concentrations. V-11-0711 can be used for the study of cervical cancer and triple-negative breast cancer[1][2].
Product Specifications
CAS Number
[1428338-79-7]
UNSPSC
12352005
Target
Apoptosis; Choline Kinase; Drug Isomer
Related Pathways
Apoptosis; Neuronal Signaling; Others
Field of Research
Cancer
Smiles
O[C@]([C@]1([H])C2CCN(CC2)C1)(C3=CC=CC=C3)CCC4=C(C=CC=C4)OC5CCOCC5
Molecular Formula
C27H35NO3
Molecular Weight
421.57
References & Citations
[1]Falcon SC, et al. A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival. Oncogenesis. 2013;2 (3) :e38.|[2]Mori N, et al. Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 2015 Dec;28 (12) :1697-706.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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