Cis-V-11-0711

Cis-V-11-0711 is the cis form of V-11-0711 (HY-120337) . V-11-0711 is a potent and selective Chk-α (IC50 = 20 nM) inhibitor. V-11-0711 can significantly reduce PCho levels. V-11-0711 causes a reversible growth arrest. V-11-0711 induces apoptosis at high concentrations. V-11-0711 can be used for the study of cervical cancer and triple-negative breast cancer[1][2].

Product Specifications

CAS Number

[1428338-79-7]

UNSPSC

12352005

Target

Apoptosis; Choline Kinase; Drug Isomer

Related Pathways

Apoptosis; Neuronal Signaling; Others

Field of Research

Cancer

Smiles

O[C@]([C@]1([H])C2CCN(CC2)C1)(C3=CC=CC=C3)CCC4=C(C=CC=C4)OC5CCOCC5

Molecular Formula

C27H35NO3

Molecular Weight

421.57

References & Citations

[1]Falcon SC, et al. A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival. Oncogenesis. 2013;2 (3) :e38.|[2]Mori N, et al. Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 2015 Dec;28 (12) :1697-706.