V-11-0711 (hydrochloride)
V-11-0711 (hydrochloride) is a potent and selective Chk-α (IC50 = 20 nM) inhibitor. V-11-0711 (hydrochloride) can significantly reduce PCho levels. V-11-0711 (hydrochloride) causes a reversible growth arrest. V-11-0711 induces apoptosis at high concentrations. V-11-0711 (hydrochloride) can be used for the study of cervical cancer and triple-negative breast cancer[1][2].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Choline Kinase
Related Pathways
Apoptosis; Neuronal Signaling
Field of Research
Cancer
Smiles
O[C@@]([C@]1([H])C2CCN(CC2)C1)(C3=CC=CC=C3)CCC4=C(C=CC=C4)OC5CCOCC5.Cl
Molecular Formula
C27H36ClNO3
Molecular Weight
458.03
References & Citations
[1]Falcon SC, et al. A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival. Oncogenesis. 2013;2 (3) :e38.|[2]Mori N, et al. Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 2015 Dec;28 (12) :1697-706.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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