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DSR-71167

DSR-71167 is an orally active mineralocorticoid receptor (MR) antagonist with an IC50 of 0.26 μM. DSR-71167 exhibits weak carbonic anhydrase (CA) inhibitory activity with an IC50 of 19 μM. DSR-71167 can dose-dependently increase urinary sodium excretion in rat models and has a very low risk of hyperkalemia in potassium-loading rat models. DSR-71167 lowers systolic blood pressure in hypertensive rat models. DSR-71167 can be used for research on hypertension and heart failure[1].

Product Specifications

CAS Number

1355687-91-0

UNSPSC

12352005

Target

Carbonic Anhydrase; Mineralocorticoid Receptor

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cardiovascular Disease

Smiles

O=C(C1=CC=C(C2=CC=CC=C2F)C(CNCC(F)F)=C1)NC3=CC=C(S(=O)(N)=O)C(OC)=C3.Cl

Molecular Formula

C23H23ClF3N3O4S

Molecular Weight

529.96

References & Citations

[1]Nariai T, et al. DSR-71167, a novel mineralocorticoid receptor antagonist with carbonic anhydrase inhibitory activity, separates urinary sodium excretion and serum potassium elevation in rats. J Pharmacol Exp Ther. 2015 Jul;354 (1) :2-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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