CB-618
CB-618 is a β-lactamase inhibitor. CB-618 reversibly covalently inhibits Ambler class A, C, and some class D serine β-lactamases. CB-618 has weak antibacterial activity as a single agent, but it significantly enhances the antibacterial activity of Meropenem (HY-13678) against enzyme-producing Enterobacteriaceae. CB-618 can be used in research on drug-resistant bacteria[1][2].
Product Specifications
CAS Number
[1463520-70-8]
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=S(ON1[C@]2([H])CC[C@@H](C3=NN=CO3)[N@@](C2)C1=O)(O)=O
Molecular Formula
C8H10N4O6S
Molecular Weight
290.25
References & Citations
[1]Papp-Wallace KM, Bonomo RA. New β-lactamase inhibitors in the clinic. Infectious disease clinics of North America. 2016 Jun;30 (2) :441.|[2]Griffith DC, et al. Pharmacokinetics/pharmacodynamics of vaborbactam, a novel beta-lactamase inhibitor, in combination with meropenem. Antimicrobial Agents and Chemotherapy. 2019 Jan;63 (1) :10-128.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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