3-Aminobenzamide (Standard)
3-Aminobenzamide (Standard) is the analytical standard of 3-Aminobenzamide. This product is intended for research and analytical applications. 3-Aminobenzamide (PARP-IN-1) is a potent inhibitor of PARP with IC50 of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.
Product Specifications
CAS Number
3544-24-9
UNSPSC
12352100
Target
PARP; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer
Smiles
O=C(C1=CC=CC(N)=C1)N
Molecular Formula
C7H8N2O
Molecular Weight
136.15
References & Citations
[1]Brock WA, et al. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly (ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18;205 (2) :155-60.|[2]Radovits T, et al. Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. Eur J Pharmacol. 2007 Jun 14;564 (1-3) :158-66.|[3]Szabo C, et al. Poly (ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes. 2006 Nov;55 (11) :3004-12.|[4]Clark RS, et al. Local administration of the poly (ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice. J Neurotrauma. 2007 Aug;24 (8) :1399-405.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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