SE 175
SE 175 is an organic nitrate compound that acts as an NO donor in vivo following reductive transformation of the nitrate group to nitric oxide. SE 175 stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC50 of 0.20 µM[1].
Product Specifications
CAS Number
258278-64-7
UNSPSC
12352005
Target
Guanylate Cyclase; NO Synthase
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Cardiovascular Disease
Smiles
O=C(OC)C1=CC=CC=C1SC(C2=CC=C(CO[N+]([O-])=O)C=C2)=O
Molecular Formula
C16H13NO6S
Molecular Weight
347.34
References & Citations
[1]Endres S, et al. NO-Donors, part 3: nitrooxyacylated thiosalicylates and salicylates - synthesis and biological activities (#) . Eur J Med Chem. 1999;34 (11) :895-901.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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