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SE 175

SE 175 is an organic nitrate compound that acts as an NO donor in vivo following reductive transformation of the nitrate group to nitric oxide. SE 175 stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC50 of 0.20 µM[1].

Product Specifications

CAS Number

258278-64-7

UNSPSC

12352005

Target

Guanylate Cyclase; NO Synthase

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Field of Research

Cardiovascular Disease

Smiles

O=C(OC)C1=CC=CC=C1SC(C2=CC=C(CO[N+]([O-])=O)C=C2)=O

Molecular Formula

C16H13NO6S

Molecular Weight

347.34

References & Citations

[1]Endres S, et al. NO-Donors, part 3: nitrooxyacylated thiosalicylates and salicylates - synthesis and biological activities (#) . Eur J Med Chem. 1999;34 (11) :895-901.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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