PF-04827736
PF-04827736 (compound (S) -3) is a selective PDE1 inhibitor with IC50 values of 9.1 nM, 38 nM and 42 nM for PDE1B, PDE1C and PDE1A. PF-04827736 selectively inhibits human PDE1 over the other 10 superfamily members (PDE2-PDE11) . PF-04827736 can be used for the study of cardiovascular disease[1].
Product Specifications
CAS Number
[2230054-75-6]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O(C)C=1C2=C(C(N[C@H](CC3=NNC(C)=C3)C)=NC=N2)C=CC1OC
Molecular Formula
C17H21N5O2
Molecular Weight
327.39
References & Citations
[1]John M Humphrey, et al. Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1. J Med Chem. 2018 May 24;61 (10) :4635-4640.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1
Curated Selection
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