PF-04677490
PF-04677490 is a PDE1 inhibitor (IC50: 21 nM) . PF-04677490 has IC50s of 21 nM, 83 nM, and 118 nM for PDE1B1, PDE1C, and PDE1A, respectively. PF-04677490 efficaciously inhibits cAMP- and cGMP-hydrolytic activity[1].
Product Specifications
CAS Number
1628342-10-8
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC(CC1=NNC(C)=C1)NC2=C3C=CC(OC)=C(C3=NC=N2)OC
Molecular Formula
C17H21N5O2
Molecular Weight
327.38
References & Citations
[1]Humphrey JM, et al. Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1. J Med Chem. 2018 May 24;61 (10) :4635-4640.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1
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